Hyphenated Chromatography Methods: Successes and Remaining Challenges | LCGC International
In an HTC-19 interview, Hans-Gerd Janssen (Unilever) reviews hyphenated chromatography in food analysis. Mass spectrometry and data processing have been the decade's biggest drivers, though accurate peak annotation and integration remain concerns; machine learning, improved spectral databases and automated QC are promising fixes. He notes the difficulty of linking LC–MS peptide data to sensory perception, discusses at-line versus fully integrated systems, and sees sensors, AI and rapid platforms enabling real-time process monitoring.